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Creators/Authors contains: "Rodriguez, Josue D"

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  1. Pediatric epilepsy due to drug-resistant Focal Cortical Dysplasia (FCD) presents significant healthcare challenges. Precise preoperative identification of FCD lesions is imperative for surgical planning and patient outcomes. This paper presents a proof-of-concept for an integrated methodology that combines Electroencephalogram (EEG)-based functional connectivity analysis with Magnetic Resonance Imaging (MRI)-derived cortical thickness measurements to identify FCD lesions in pediatric epileptic patients. We examined a single-case clinical scenario from Oregon Health Science and University, consistently identifying the Caudal Middle Frontal (cMFG) region across both EEG and MRI modalities, a finding that was confirmed in the postoperative MRI scan. This cross-validation underscores the potential of the precision of our approach in pinpointing the surgical target region. Despite being constrained by its preliminary nature, our research offers a valuable foundation for a personalized, rigorous method of detecting the location of the FCD lesions. It holds significant clinical implications for managing FCD-related epilepsy. It also portends broader applications in neurology and precision medicine. Nonetheless, further large-scale studies are needed to validate and fine-tune our methodology. Clinical Relevance - This study offers clinicians an advanced, integrated approach to preoperative assessment of FCD lesions, potentially improving the precision of surgical planning in pediatric epilepsy. 
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